Several studies about the treatment of heart disease (congestive heart failure, cardiomyopathy, and/or valvular heart disease) concluded that a CoQ10 supplement of between 50 and 300 mg per day appears to be the optimal dose. The primary action of CoQ10 in clinical hypertension is vasodilatation. It acts directly on the endothelium and vascular smooth muscle, with the ability to counteract vasoconstriction and lower blood pressure without significant side effects.
The therapeutic use of the CoQ10 supplement is based on its fundamental role in the mitochondrial function and cellular bioenergetics. It is taken up in large doses by all tissues, including the heart and the brain mitochondria.
CoQ10 is involved in energy (ATP) production of the body. The highest concentration of CoQ10 in the body is in the heart muscle. The CoQ10 can profoundly increase the cardiac function by enhancing the pumping capacity of the heart.
The result would be an increase in the production of energy in the heart muscle cells. It is obvious that its reduction in a cell impairs the respiratory chain in the mitochondria that leads to an electron jam.
The CoQ10 content in cells declines during aging, especially those in the muscle cells. Its levels are lowered in skin cells, which suggest a decrease in mitochondrial CoQ10 content.
However, in some tissue, such as the aged skin, a supplementation of CoQ10 can restore normal levels, where a reduction in wrinkle depth following the application has been shown in clinical studies.
The CoQ10 supplement is effective against the UVA mediated oxidative stress in human keratinocytes and prevention of the oxidative mtDNA damage. It is also able to significantly suppress the expression of the collagenase in human dermal fibroblasts following UVA irradiation.
One of the studies found that CoQ10 has the efficacy to prevent many of the detrimental effects of photoaging and has general energizing effects on the human skin. Apparently, cutaneous ageing is characterized by a decline in the energy metabolism of skin cells, which is partially caused by the detrimental changes in the mitochondrial respiration.
The process seemed to be predominantly mediated by free radical actions generated either by the UV light or an impaired mitochondrial respiration associated with leakage of electrons from the respiratory chain.
An alteration in the mitochondrial respiration can be regarded as an important consequence of ageing. Any lack of mitochondrial function impairs the cellular ATP synthesis, thus reducing the fuel supply for repair mechanisms.
This coenzyme acts as an antioxidant that helps to reduce age related damage caused by free radicals. More importantly, it helps the body produce cellular energy in the form of adenosine triphosphate (ATP).
The human body needs this coenzyme to get it going due to its energy producing function and its double function ability to act as an antioxidant. The CoQ10 declines with age, but can be effectively replenished in the skin through topical formulations.
Great antiaging supplement
A study about the effect of in vivo CoQ10 supplementation on the DNA repair enzyme expression found that cellular extracts from CoQ10 enriched lymphocytes exhibit a markedly higher DNA repair activity compared to the native and wash out lymphocytes, which indicates that supplementation improves DNA repair.
Oxidative stress is caused by an overproduction of ROS, and shifts in the balance between oxidants and antioxidants in favor of the oxidants, producing damage to cell structures and consequently leading to various diseases and ageing.
The importance of the CoQ10 is not just as an agent for energy transduction in mitochondria. New findings show that CoQ10 is an important antioxidant with the unique feature of regenerating redox capacity.
The biosynthesis in mitochondria and in the endoplasmic reticulum provide sufficient CoQ10 in normal individuals. Evidence for deficiency is based on genetic failure, and mainly on ageing and age related diseases.
The important properties of CoQ10 make this molecule an essential dietary supplement designed to delay and mitigate its deficiency in the body. The beneficial effect of CoQ10 is reinforced because this antioxidant has an excellent safety record and is well tolerated in high doses for prolonged periods of time with few side effects.
Some antioxidants and interventions related to dietary fat have proven to be useful as dietary antiaging therapies. The CoQ10 is an important mitochondrial redox component and endogenously produced lipid soluble antioxidant of the human organism.
It plays a crucial role in the generation of cellular energy, enhances the immune system and acts as a free radical scavenger. Ageing, poor eating habits, stress and infection affect the human body’s ability to provide adequate amounts of CoQ10.
After the age of about 35, the body begins to lose the ability to synthesize CoQ10 from food and its deficiency develops. Many researchers suggest that using CoQ10 supplements alone or in combination with other nutritional supplements may help maintain the health of the elderly people or treat some of the health problems or diseases. Therefore, an oral supplementation with CoQ10 may be very helpful for the skin health.
Great for the heart
Although, taking a CoQ10 supplement has been reported beneficial in treating a variety of health conditions and diseases in more than 200 clinical trials investigating its use as a drug or dietary supplement, more research is needed to determine the appropriate dose, effectiveness, and bioavailability of orally administered CoQ10, especially in the elderly population.
At the conclusion of the 1986 conference, the Nobel Prize winners reported their research about CoQ10. In the Aging Without Growing Old, the following remarks were made by Dr. Folkers
“We have heard that patients in advanced cardiac failure, who had only a few months to live, under close medical care, have revealed almost miraculous improvement after treatment with CoQ10, and such is a step of progress in cardiology.”
The supplementation can be beneficial for those who frequently experience discomfort with any physical exertion, and often have pain even when they are at rest. The use of the CoQ10 supplement to treat heart disease has become well established in Japan, where results showed about 705 improvement of the patients in completed 25 studies.
Researchers have treated heart failure patients with CoQ10 supplement and have shown considerable success. The coenzyme has been shown to enhance the pumping capacity of the heart and likely eliminated the major side effects associated with conventional heart failure drugs.
In general, the more severe the heart failure condition, the greater the benefit. The cellular production of CoQ10 drops during aging. Fortunately, the CoQ10 occurs in some food, the dietary sources with the highest levels of CoQ10, such as organ meats, are still at insufficient levels to make up for the lowered production associated with ageing.
CoQ10 has been implicated as a potential therapy in a large number of health conditions and diseases, especially those that result from a reduced mitochondrial function. One study found that a CoQ10 supplement can slow down the progression of numerous neurodegenerative diseases, especially those in which their etiology involves impaired mitochondrial function and oxidative stress.
Low blood levels of CoQ10 have been found in people with hypertension, but it is not clear if CoQ10 deficiency is the cause of the high blood pressure. In one study, a deficiency of CoQ10 was found in 39% of patients with hypertension, compared to 6% of those with normal blood pressure.
Providing their patients with 60 mg of CoQ10 for 8 weeks resulted in a 10% or greater decrease in blood pressure. In one double blind study, they found that 20 hypertensive subjects with low serum CoQ10 levels and receiving 100 mg of CoQ10 per day for 12 weeks showed a significant reduction in systolic and diastolic blood pressures.
How do you get CoQ10?
This coenzyme, also known as ubiquinone, is a potent antioxidant found in the mitochondria of our muscles and organs, particularly in the heart, liver, kidneys and pancreas. It can be obtained through food sources that include animal meats and seafoods.
Several studies have been quite promising in a number of health related areas, including improved appearance. Its antioxidant strength prevents damage to the body’s collagen and elastin production processes.
Recent studies show that CoQ10 supplements can significantly increase the HDL-C and the ApoA1 levels, even in people taking statins, and may help reduce risk for CVD. Taking CoQ10 supplements also lowers levels of inflammatory biomarkers shown to be risk factors for CVD, such as high-sensitivity C-reactive protein.
Finally, low CoQ10 levels have been associated with greater tissue damage to the heart during a heart attack and the brain during a stroke. The CoQ10 supplement was hailed as the first new drug to improve heart failure mortality in over a decade.
Challem, J., & Evans, S. (2004). Anti aging nutrients. North Bergen, NJ: Basic Health Publications Inc.
Cutler, R. G., & Rodriguez, H. (2003). Critical reviews of oxidative stress and aging: Advances in basic science. River Edge, NJ: World Scientific.
McFarland, Judy L., & McFarland, L. G. (2003). Aging without growing old. Lake Mary, Florida: Siloam Press.
Farage, M. A., Miller, K. W., & Maibach, H. I. (2010).
Textbook of aging skin. Heidelberg: Springer-Verlag.
Preedy, V. R. (2014). Aging: Oxidative stress and dietary antioxidants. Waltham, MA: Academic Press.
In a randomized clinical trial, patients who received CoQ10 supplement soon after a heart attack had a much lower rate of subsequent cardiac events over the next year than a control group (24.6 percent versus 45 percent). About half the patients in both groups were also taking a statin medication, prompting the researchers to report that, “treatment with CoQ10 in patients with recent heart attack may be beneficial in patients with high risk of atherothrombosis, despite optimal lipid lowering therapy.”
Another 10 year study conclusively showed that CoQ10 supplementation significantly improved survival for even the most severe heart failure patients while radically reducing incidences of hospitalization. This new study shows that a CoQ10 supplementation can restore deficient CoQ10 levels in patients with moderate-to-severe heart failure, extend lifespan, and improve quality of life.
After only three months of supplementation, the researchers detected a trend towards reduced levels of a blood marker of heart failure severity that is released from over-worked heart muscle cells.1,2 At two years, significantly more treated patients had improved measurements of heart function than did placebo recipients. One thing to remember – take the CoQ10 supplement with meals!