The glutathione supplement is the one nutrient you need for your skin care anti aging regimen with unparalleled benefits. In fact, glutathione is a kind of antioxidant present in almost every cell in the body that impacts various systemic processes, including acting as a regulator of the melanogenic pathway. Previous studies showed that supplementation of a reduced form of glutathione (GSH, 500 mg/d) has skin lightening efficacy in humans. Subjects also showed reduction in face wrinkles and tendency towards increased skin elasticity.
The glutathione has been claimed by many as quite effective for skin whitening. It is made up of three amino acids cysteine, glycine and glutamate.
It is generally considered safe for oral use as a diet supplement and arguably, the most important antioxidant in the body that is also associated with beneficial skin health outcomes. However, besides from being expensive, you should be aware that there has been no consistent clinical data reporting about its efficacy.
The glutathione enzyme has the ability to regenerate the other antioxidants within the skin, detoxify, protect from UVR, and provide skin lightening benefits. Maintaining a generous amount of this antioxidant can help maintain optimal skin health.
Glutathione has been cited in over 100,000 scientific articles as the mother of all antioxidants, which gave us a good insight about its significant role in vital intracellular and extracellular functions. It detoxifies the liver, transports the amino acids, and inhibits the tyrosinase activity.
It has become more popular and accessible these days because of its aging skin care abilities. The lack of glutathione is associated with a weaker immune system, elevated oxidative stress, and aging.
Aside from detoxifying and reducing free radicals, the antioxidant protects the skin cells from near visible UVA and UVB radiations. It is the automated DNA repair mechanism of damaged cells.
It serves as the body’s natural detoxified that helps reduce wrinkles and dry spots. Sort of reverse aging. Reversing graying hair to its natural color is one of the side effects of this enzyme.
Without the protection of glutathione, cells die at a faster rate, and makes you age more quickly. The reason for this is our exposure to environmental toxins.
The greater the exposure to toxins, the faster the body uses up its supply of glutathione. For example, people who smoke are chronically exposed to toxins and almost always suffer from inflammatory conditions.
Because its vicious cycle depletes the supply of glutathione and increases health risks, you need to get it from the food you eat or as a supplement. Supplements can be in the form of injections or capsules.
Glutathione is very powerful in targeting and destroying free radicals. It protects the cells from potential harm such as cigarette smoke, smog, and other toxins. It is considered as one of the most extraordinary overall health boosters in the world of modern nutritional medicine.
GSH has been known to effectively enhance the immune system and has the right properties that can boost the immune system and support your antiaging skincare. This natural protein can be derived from fresh, raw fruits and vegetables.
If you want how to increase your supply of glutathione, you can start by eating fresh fruits and vegetables. They provide excellent level of glutathione, such as avocado, walnuts, and asparagus. Try the following
- Brussels sprouts
A healthy immune system is what you need as you age. The most amazing function is its ability to round up and neutralize the toxins polluting the body systems.
The glutathione antioxidant system is composed of glutathione, glutathione peroxidase, and glutathione reductase. It is closely associated with nutrition, exercise, and stress.
Taking the antioxidant can help keep your cells healthy, and also, keep yourself free from almost any diseases. Whenever a cell is under severe oxidative stress, it is glutathione that comes to the rescue.
Skin whitening or weight loss?
Is glutathione for skin whitening or for weight loss? The answer is that you can shape up and enhance your immune system by increasing your level of glutathione and be happy with its skin lightening side effect.
There is no other side effect that can make me happy, but a whiter glowing skin! Having an adequate glutathione is important for continued weight loss.
When you lose weight, it gets used up faster. Lose a few extra pounds but make sure you also take care of your GGSH levels. Because of its wide range of uses in the body, it is critically important to prevent glutathione levels from becoming low.
What makes glutathione important?
The depletion of the antioxidants ascorbic acid, uric acid, and glutathione depend on the human bronchoalveolar lavage fluid exposure to 0.05 to 1 ppm ozone. Ozone depletes Vitamin C and uric acid from the fluid in a time and concentration dependent manner.
However, the rate of depletion is variable. In human bronchoalveolar lavage fluid, the order of reactivity with ozone is Vitamin C >> uric acid >> glutathione.
Glutathione is linked to perception of cellular redox imbalance contributed by signal amplification. Glutathione levels are highly significant in adapting extreme heavy metal stress and response to heavy metal stress.
The lack of it in the cells is considered as the foremost cause of premature aging. This is one reason you should consider taking the glutathione supplement as part of your anti aging care. Here are some antiaging benefits
- Rejuvenates immunity
- Blocks cell damage by breaking down free radicals
- Rejuvenates weak and old immune system
- Helps prevent macular degeneration
- Prevents oxidation of blood cholesterol into becoming toxic
- Prevents age related osteoporosis
- Prevents shock induced behavioral depression
- May limit neurodegeneration
- Increases memory in subjects with Alzheimer’s
- Prevents Parkinson disease
- Improves mitochondrial health
- Protects and may heal the gut
- May help treat diabetes complications
- May prevent kidney disease
- Reduces oxidative stress and prevents damage in the liver
- Improves sleep quality
- Reduces acne
- May treat rheumatoid arthritis
- Prevents glaucoma and cataracts
- May treat cystic fibrosis
Extensive research and clinical trials have demonstrated glutathione to enhance the immune response system by raising the fighter T cell levels in the lymphocytes, neutralizing the free radicals, and regulating the other antioxidants.
It detoxifies the liver, removes 12 known carcinogens from the cells, and suppresses the growth of tumors. If you become deficient, toxins can build up like overflowing dumpsters during a garbage strike.
For example, glutathione mercury complexes are the primary way by which mercury is eliminated from your body. If you consume a great deal of fish, the total mercury retained in your tissues directly depends on your glutathione stores.
The coordinated role of the glutathione ascorbate to alleviate metal stress in plants was significant. Ascorbate and glutathione are important in choroplastic protection against the potentially hazardous effects of ROS.
They act as direct antioxidants and impacts redox sensing and signalling. The protection against oxidative stress by scavenging ROS is mediated by components of enzymatic and non-enzymatic antioxidant system of the ascorbate and glutathione pathway.
It benefits the body by providing more protection from bacterial and viral infections as well as support for the detoxification of carcinogens and pollutants. It serves to reduce damage to the mitochondria, thus preventing cellular decline and aging.
The tripeptide GSH is one of the oldest members of the peptide family. It contains SH bearing cysteine amino acid that promotes its antioxidant activity.
One of the most popular claims is the repair or restoration of the extracellular matrix of the skin, which mainly reduces the appearance of wrinkles. This is why your body must continuously replenish its GSH by making more.
What can you expect from a declining level?
Data from normal subjects measuring cysteine/cystine and glutathione/glutathione disulphide ratios suggest that there is a slow linear capacity of the glutathione antioxidant system maintained until the age of 45, followed by a relatively rapid decline. This finding is significant in correlating the development of pressure ulcers among the elderly.
In a normally healing wound, tissue concentrations of enzymatic and non-enzymatic antioxidants fall during healing as part of the healing process. It is possible that the failure of the host to respond appropriately to ROS signals, particularly due to the aging process, leads to vulnerability to oxidative stress.
This changes the way the signals are being systematically sent by the redox signalling mechanisms. The changes in the redox signalling may be associated with age related pro-oxidative shift.
Low glutathione levels are implicated in immune compromised individuals, neurodegenerative diseases, such as MND, Alzheimers, Parkinsons, atherosclerosis, cataracts, and diabetes.
The level of glutathione in the mitochondria might be even more important than the level of glutathione in the rest of the cell. Mitochondrial glutathione levels diminish more with age than do the levels in the rest of the cells. This decline makes the mitochondria more susceptible to oxidative damage.
Glutathione is produced in the body, but not easily absorbed when taken orally. The ingestion of glutathione has little or no effect on the level of the substance in cells.
The Immunocal supplement has been introduced to the market to help raise the levels of glutathione. However, the main ingredients are milk proteins. You should not take this supplement if you have allergies to such proteins.
Immunocal is a natural health supplement produced by a company called Immunotech that contains a complete protein, which means that it supplies all of the amino acids your body needs to operate efficiently.
The touted benefits of Immunocal are primarily attributed to the fact that it is a rich source of the amino acid cysteine.
According to the University of Maryland Medical Center, cysteine is converted into a powerful antioxidant called glutathione. Immunocal is sold as a powder and can be mixed with liquids such as orange juice or water.
Immunotech recommends using a slow-speed mixer or stirring the product by hand to reduce the risk of breaking the fragile protein bonds and lowering the efficacy of the supplement.
Immunotech warns that people with an allergy to milk proteins and those undergoing immunosuppresive therapy should not use Immunocal. People following a protein-restricted diet will need to calculate the 9 g of protein provided by each pouch of Immunocal.
Abdominal cramps and bloating are occasional side effects and a rash is possible, but rare. If a rash occurs, discontinue use of the product immediately.
Large doses, exceeding 7 g, of cysteine can be toxic. Always consult your doctor before you begin to use any supplement.
How to increase your glutathione levels?
A healthy diet filled with fruits and vegetables is the best way to make your body produce glutathione by itself. Fresh, raw fruits and vegetables have typically enough glutathione levels.
Especially rich sources of glutathione are raw avocado, watermelon, fresh asparagus, grapefruit, and baked acorn squash. It is also found in walnuts, orange, peach, potato, spinach, tomato, and orange juice.
The consumption of some vegetables, such as broccoli, cabbage, Brussel sprouts, cauliflower, kale, and parsley in human diets contributes in first, by providing the naturally occurring GSH and second, by stimulating the human body to self-produce this powerful antioxidant.
A shimmer of hope for me. Promoting vitiligo repigmentation is still a matter of debate.
Anjum, N. A. (2010). Ascorbate-glutathione pathway and stress tolerance in plants. New York: Springer.
Bader, D. L., Bouten, C. & Colin, D. (2005). Pressure ulcer research: Current and future perspectives. Germany: Springer.
Braverman, E. R. (2003). The healing nutrients within: Facts, findings, and new research on amino acids. Laguna Beach, CA: Basic Health Publications.
Icheku, V. (2006). Degenerative diseases of aging: Causes and preventions. London: William Jacob Pubishers.
Murray, M., Pizzorno, J., & Pizzorno, L. (2005). The encyclopedia of healing foods. New York: Atria Books.
Obagi, Z. E. (2015). The art of skin restoration and rejuvenation second edition. Boca Raton, FL: CRC Press.
Sen, C. K., Packer, L. & Hanninen, O. (2000). Handbook of oxidants and antioxidants in exercise. The Netherlands: Elsevier Science.
It is very difficult to optimize GSH levels through diet alone. A large percentage of oral glutathione breaks down and oxidizes in the digestive tract, with only a small fraction making it into your bloodstream, tissues and cells.
Though supplementation with glutathione has been around for years, few people were aware of it because until recently, the only way to take it was through an IV. Oral forms weren’t very successful because they were poorly absorbed. The stomach diligently breaks down about 90% of it.
Eating fruits and vegetables plus exercise can boost glutathione levels. Physical activity increases glutathione. In particular, a combination of cardio and weight training is most effective.
The glutathione antioxidant is a well kept anti aging secret. Maintain youthful look and sustain wellness. The enzyme removes toxins and keeps you young all over. Slow down aging and keep your body fit and slim.