The antiaging effects of the glutathione supplement made the celebrities dish out a few thousand dollars each month for an IV glutathione injection. To mention a few of the effects of a raised glutathione level, I would practically start with its anti ageing plus skin lightening properties. This antioxidant supplement strengthens the immune system and raises the energy levels, which oftentimes lead to an improved athletic performance and recovery. Maintaining sufficient levels of glutathione can protect you from the onset of degenerative diseases.
The pathogenesis of vitiligo has not been clarified yet, but it has already affected about 2% of the world’s population. Multiple mechanisms such as autoimmune, neuronal, endocrine and oxidative stress resulting from unbalanced antioxidant defense system have been proposed to explain its occurrence.
One study confirmed the antioxidant imbalance that appears to be a consequence of a mitochondrial impairment. This finding supports the concept of a possible systemic oxidative stress in vitiligo. Increase in lipid peroxidation results in hair graying and pathological conditions like vitiligo depigmentary natural processes.
Oxidative stress is well known to induce an antioxidant response. On the other hand, the glutathione is a tripeptide present in all mammalian tissues that plays an important role in modulating critical cellular processes like DNA synthesis, maintaining a healthy immune function, and scavenging free radicals. Definitely, the glutathione supplement contributes to the body’s defense against oxidative stress in various ways.
It is vital for detoxification, because it actually gets into the cells, which is paramount in maintaining good health and a youthful system. The GSH can even prevent viral infection, considering that it binds to the viral cell surface and cripples it so it cannot penetrate the cell.
YOU MAY WANT TO READ THIS
Glutathione and the free radicals
You should know by now that the virus cannot get you if it cannot get into your cell and replicate itself. The association of the glutathione with the immune system and the association of the immune system with the vitiligo has been well established.
Autoantibodies directed specifically against the melanocyte cell surface antigens have the ability to kill melanocytes in vivo and in vitro. From the viewpoint of preventing and treating depigmentation, it may be useful to consider how the antioxidant response following RD (rhododentrol) exposure protects the melanocytes from RD.
Take note that melanocytes can survive RD exposure for as long as glutathione is sufficiently maintained. Cells are vulnerable to RD, but RD only exerts its cytotoxicity when oxidative stress overwhelms the cellular antioxidant response. In conclusion, the study revealed the crucial role that glutathione plays in the survival of RD exposed melanocytes.
Furthermore, the oxidative stress has been perceived to play an important pathogenic role in vitiligo. Several studies suggest the accumulation of free radicals toxic to the melanocytes can lead to their destruction. The lesional skin of vitiligo patients showed a lack of melanocytes.
One incident was the launched of a highly effective skin lightening cream by the Kanebo cosmetics company in 2013. Consumers who used it developed the vitiligo because of its phenol ingredient that resembles tyrosine.
Phenolic compounds are believed to trigger or worsen vitiligo by killing the melanocytes in the skin through oxidative stress. It also causes an overload of hydrogen peroxide in the skin.
The vitiligo is characterized by depigmented skin patches due to loss of epidermal melanocytes. Oxidative stress has been observed to play on its onset, while the autoimmunity causes the disease progression.
Some individuals who came in contact with phenolic compounds or monobenzyl ether of hydroquinone can cause a depigmenting disorder. Vitiligo has always been seen progressive throughout the life of the individual, but there is a chance to stop the depigmentation caused by the chemicals when the offending agent has been removed.
You can boost your immune system with a glutathione injection. A cocktail of glutathione, Vitamin C and collagen intravenous shots can help battle pigmentation. This will start to take effect after a few sessions given over a span of a few months.
Remember that the glutathione plays a crucial role in the survival of the RD-exposed melanocytes. Glutathione is a major endogenous antioxidant scavenging free radicals and toxins, such as lipid peroxides that would otherwise damage the cells.
A less GSH level is associated with most of immune and degenerative diseases in ageing and one of these is the vitiligo. Reversing the oxidant-antioxidant imbalance that is considered to play a role in the pathogenesis of this disease may relieve oxidative stress.
The dosage for the consumption of glutathione as an anti oxidizing agent is 20 to 30 mg per kg of body weight and for consumption of glutathione as a whitening agent should be 20 to 40 mg per kg of body weight. To maximize its effects, it should be taken with Vitamin C and ascorbic acid.
Many researchers believed the ability of the glutathione supplement to enhance the body’s immune system. A depletion of it can gradually result in illness.
There are over 100 diseases and conditions associated with low glutathione levels. Most people who are severely ill have been found to have low levels of glutathione. What factors deplete glutathione?
- Other drugs
- Vigorous exercise
- Ultraviolet radiation
- Air pollutants
- Hormone mimicking chemicals
Most of the degenerative diseases of ageing and the autoimmune diseases have been studied and linked to low GSH levels including, acetaminophen poisoning, ADD, Addison’sdisease, AIDS, alopecia areata, ALS, Alzheimer’s diseases, anemia, ankylosing spondylitis, arteriosclerosis (hardening of the arteries), arthritis, asthma, autism, autoimmune disease, burns, cachexia, cancer, candida infection, cardiomyopathy, Chronic Fatigue Syndrome, colitis, coronary artery disease, cystic fibrosis, diabeter, Crohn’s disease, eczema, emphysema, Epstein Barr Viral (EBV) syndrome, fibromyalgia, free radical overload, Grave’s disease, hepatic dysfunction (liver disease), hepatitis B, hepatitis C, hypercholesterolemia (high blood cholesterol), herpes, infections (viral, bacterial, antifungal), inflammatory bowel diseases (IBD), lupus, macular degeneration (diabetic and age related macular degeneration), malnutrition, Menier’s disease, multiple sclerosis, Myasthenia Gravis, neurodegenerative diseases, nutritional disorders, Parkinson’s disease, primary biliary cirrhosis, progeria, psoriasis, rheumatic fever, sarcoidosis, scleroderma, shingles, stroke, surgery, toxic poisoning, trauma vasculitis, vitiligo, Wegener’s Granulomatosis.
I am surprised by this finding! The level of glutathione in the cell is predictive of how long you live. This miraculous antioxidant is needed by the liver to survive.
Without it, the liver would soon become overwhelmed by the accumulation of toxins, which would result in the organ failure and death. Glutathione is likely to get more attention in the near future, as experts begin to roll out and connect the dots between depleted stores of antioxidants and the likelihood of chronic diseases.
Vitiligo can be the result of oxidative stress from elevated H2O2 and NO and decreased catalase and erythrocyte glutathione. There is a linked with a family history of premature graying to autoimmune disorders and vitiligo.
Studies have shown the catecholamine induced oxidative stress among vitiligo patients may have involved a free radical damage. There are several factors that may have caused the destruction of the melanocytes, which includes the neural and autoimmune disorders, oxidative stress, and an inherent defect theory.
Among these factors, the oxidative stress has been seen as the most well established trigger factor for melanocyte degeneration. In this particular journal, researchers found that the glutathione levels in more active vitiligo cases were consistently lower compared to the GSH levels in the less active cases. However, the GSH levels cannot be considered as a marker for vitiligo lesions.
It has been concluded that a reduced erythrocytic or systemic GSH levels are a distinctive feature of vitiligo patients. It is reasonable to assert that GSH is systematically exhausted to neutralize free radicals. Additionally, smoking should be prohibited in vitiligo patients to prevent the possible aggravation of the condition.
Having significant amounts of glutathione makes moving toxins out of the cell and out of the body easier. This antioxidant supplement should be a part of your antiaging care to prevent age related diseases not to mention the fact that it has been studied as therapy for cancer, heart disease, to help enhance the immune system, and slow the aging process.
Glutathione plays a very crucial role in preventing cancer, especially liver cancer. It is perceived to target carcinogens, make them soluble, and help the body flush them out.
Melanocytes possess a protective mechanism to eliminate the toxic melanin precursors and the free radicals. In the absence of sufficient glutathione, the reactive oxygen species produced by the body can damage or completely destroy the melanocytes.
The common symptoms of vitiligo are the white patches, premature graying of the hair, loss of color in the retina, and the loss of color in the mucous membrane (lines inside the mouth).
One treatment is the melanocyte transplantation, where the normal melanocyte has been cultured from a skin sample and then transferred the new cells into the depigmented patches. The rate of the vitiligo pigmentation may be slow or rapid.
Segmental vitiligo is restricted to one part of the body and is less likely to be associated with autoimmune diseases. Trauma and sunburn can precipitate both the segmental vitiligo and generalized vitiligo.
GSH is an extremely important cell protectant and is the essential cofactor of many enzymes. It is crucial to the homeostasis and in stabilizing the cellular biomolecular spectrum as well as in facilitating cellular performance and survival.
People take glutathione for treating cataracts and glaucoma, preventing ageing, treating or preventing alcoholism, asthma, cancer, heart disease (atherosclerosis and high cholesterol), hepatitis, liver disease, diseases that weaken the body’s defense system (including AIDS and chronic fatigue syndrome), memory loss, Alzheimer’s disease, osteoarthritis, and Parkinson’s disease.
Glutathione is also used for maintaining the body’s defense system (immune system) and fighting metal and drug poisoning. The glutathione is involved in many processes in the body, including tissue building and repair, making chemicals and proteins needed in the body, and for the immune system.
Baker, D. (2013). Glutathione – there’s no life without it second edition.
Balch, P. A. (2006). Prescription for nutritional healing. London: Penguin Books Ltd.
Challem, J. (2004). User’s guide to antioxidant supplements: Discover how natural antioxidants can reduce your risk of heart disease, cancer, and Alzheimer’s disease. NJ: Basic Health Publications Inc.
Elsner, P. & Maibach, H. I. (2000). Cosmeceuticals: Drugs vs. cosmetics. New York: Marcel Dekker Inc.
Halder, R. M., & Chappell, J. L. (2009). Vitiligo update. Retrieved from Elsevier.
Hann, S. K., & Nordlund, J. J. (2000). Vitiligo: A monograph on the basic and clinical science. MA: Blackwell Science.
Harris, J. E. (2014). Speaking of vitiligo. Retrieved from umassmed.edu.
Kondo, M. et al (2016). Glutathione maintenance is crucial fr survival of melanocytes after exposure to rhododendrol. Pigment Cell & Melanoma Research. doi/10.1111/pcmr.12494/pdf
Perricone, N. (2010). Forever young: The science of nutrigenomics for glowing, wrinkle free skin and radiant health at every age. New York: Atria.
Rehman, A. (2013). From dark skins to white masks, the gori details of women’s quest for fairness. Retrieved from Tribune.
Shin, J. W., Nam, K. M., Choi, H. R., Huh, S. Y., Kin, S. W., Youn, S. W., Huh, C. H., & Park, K. C. (2010). Erythrocyte malondialdehyde and glutathione levels in vitiligo patients. Annals of Dermatology, 22(3), 279-283.
Tate, S. A. (2016). Skin bleaching in black atlantic zones: shade shifters. Hampshire: Palgrave Macmillan.
Glutathione is a substance produced naturally by the liver and also found in fruits, vegetables, and meats. It is an antioxidant that also helps metabolize nutrients and toxins, regulate cellular processes, cell division, cell death, DNA and protein synthesis, and hormone production.
Glutathione is a peptide composed of three condensed molecules, which plays a central role in maintaining the redox potential (oxidizer/reducer balance) within our cells. In addition to the impact of its reduction on the incidence of age-related diseases, glutathione appears to play a role in apoptosis (the programmed death of our cells).
The oxidative stress is caused by natural wear and tear, environmental toxins, or stress. It is the process where the body begins to produce more free radicals that can damage and change the DNA. Oxidative stress and melanocyte survival may be influenced by glutathione supplementation and a diet high in antioxidants.